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Institute of Neuroscience and Medicine
Molecular Organization of the Brain (INM-2)

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Our scientific focus is on the in vivo decoding of molecular, cellular and systemic basics of brain function/dysfunction and their dynamic changes by means of imaging techniques.

Thematically, we investigate the physiological basis of brain function and its adaptation from short-term circadian fluctuations (e.g. role of the adenosine system in the sleep-wake rhythm) to lifelong changes (aging of the brain). We are also interested in molecular pathomechanisms of brain diseases (e.g. protein aggregation in neurodegenerative diseases) and the resulting plastic compensation and reserve mechanisms.

Methodologically, modern methods of molecular imaging (PET) but also of structural and functional imaging (MRT, MRS, fMRT) as well as electrophysiological and neurochemical methods are used in model organisms, volunteer and patient studies. Also the development of new methods for image data analysis as well as the co-development and translation of new imaging methods (e.g. new radiotracers) up to clinical/diagnostic applications belong to our fields of interest.



Molekulares Neuroimaging

Molecular Neuroimaging

The focus of our research is on metabolic and neurochemical processes which underlie fundamental functions of the brain (e. g. sleep-wake regulation) and neurological and psychiatric diseases (e.g. dementia, depression). More: Molecular Neuroimaging …



The Optophysiology Laboratory investigates the neural circuits of decision-making in mice navigating in virtual reality. More: Optophysiology …


Using PET for the Evaluation of Innovative Analgetics with Dual Mode of Action (Dual²PET)

Innovative drugs targeting two modes of action based on one chemical structure are a promising novel therapeutic approach in medicine. More

Diurnal metabolic changes in human brain

Diurnal metabolic changes in human brain


Awake Animal PET

Positron emission tomography in awake animals



Impact of electroconvulsive therapy on the adenosine A1 receptor in the human brain of depressive patients




Imaging synaptic plasticity in therapeutic sleep deprivation for major depression More

PET imaging of A2A adenosine receptors

Preclinical evaluation of a 18F-labelled A2A adenosine receptor ligand for in vivo brain imaging More: PET imaging of A2A adenosine receptors …

PET Kaffee


Habitual Daily Coffee Intake to Ensure Optimal Cognitive Performance in the Face of Chronic Sleep Restriction? More