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Svenja Caspers

Prof. Dr. med. Dr. rer. pol. Svenja Caspers

Groupleader

Degree: Physician, Dipl. Business Economist, Dipl. Political Economist

Research Group Connectivity

Director of the Institute of Anatomy I, Heinrich-Heine University Düsseldorf

Research Topics

My research focuses on understanding the interindividual variability of the human brain, particularly in the process of aging. Environmental, lifestyle and genetic factors contribute to the variability of the structure, functional architecture and connectivity of the aging brain. Using high-throughput neuroimaging analytics via automated pipelines on high-performance computing clusters on data from large population-based cohorts such as the 1000BRAINS study or the German National Cohort (NAKO), the different contributions of these interlinked factors to the aging process are assessed. Modern approaches such as machine and deep learning algorithms are integrated to enable identification of early markers and groups of subjects with common characteristics in their aging profiles. Within the Human Brain Project (HBP), these insights are linked to simulation and modelling approaches to further understand the mechanisms of brain aging. Together with the Institute for Anatomy I, University of Düsseldorf, further characterization of these brain changes in-vivo is enabled by dedicated analyses in post-mortem tissue.

Methods and Tools

  • Multimodal MRI (structural, resting-state functional, diffusion-weighted)
  • High-throughput neuroimaging analytics using high-performance computing (HPC)
  • Structural connectivity analyses in-vivo (diffusion MRI) & post-mortem (polarized-light imaging (PLI))

Addresses

Institute of Neuroscience and Medicine (INM-1)
Forschungszentrum Jülich
52425 Jülich
Institute for Anatomy I
Heinrich-Heine University Düsseldorf
Universitätsstr. 1
40225 Düsseldorf

Contact

Phone: +49 2461 61-1742
Fax: +49 2461 61-3483
email: s.caspers@fz-juelich.de